Naim Matasci
Research data infrastructure that lets AI-driven discovery compound across projects.
I build the computational platforms that research organizations run on — the orchestration layers, systems of record and data pipelines that let machine learning methods accumulate value across projects instead of being rebuilt for each one. I have done this twice: for the plant sciences, as Scientific Lead of the NSF's iPlant Collaborative (later CyVerse), and for cancer research.
I have been at the Ellison Medical Institute in Los Angeles since 2014, in progressively senior roles across data management, analytics, bioinformatics and computational biology, and am now Senior Director, Applied AI Research. My group works across AI-driven molecular design, computational pathology, and the clinical and genomic data platform underneath both. I am also a Visiting Scholar at Harvey Mudd College.
Recent work includes AI methods for designing molecules against targets that conventional approaches reach poorly, and foundation-model studies predicting treatment response from breast cancer histopathology.
My doctoral work was in evolutionary genetics at the Max Planck Institute for Evolutionary Anthropology in Leipzig, with Svante Pääbo.
Selected work
- Monitoring the rate and variability of somatic genomic alterations using long-read sequencing Scientific Reports, 2025 · co-corresponding author
- Recommendations for Generative AI in the Biological and Biomedical Sciences FASEB Generative AI Task Force, 2025
- CanvOI, an oncology intelligence foundation model: scaling FLOPS differently Preprint, 2024
- Imaging-based machine learning analysis of patient-derived tumor organoid drug response Frontiers in Oncology, 2021
- Data access for the 1,000 Plants (1KP) project GigaScience, 2014 · first author
- The iPlant Collaborative: cyberinfrastructure for plant biology Frontiers in Plant Science, 2011
Selected talks and posters
- Prediction of pathologic complete response from histopathology images of HER2+ breast cancer using an AI foundation model San Antonio Breast Cancer Symposium, 2025 · poster · last author
- Detecting obesity-associated histopathology characteristics in breast cancer using an AI foundation model AACR Special Conference: Artificial Intelligence and Machine Learning, 2025 · poster · last author
- An interactive multidimensional image data management and analysis system to support AI applications SLAS International Conference, San Diego, 2023 · SLAS AI Data Pipelines for Life Sciences Symposium, Seattle, 2022
- Unleashing the power of AI in digital pathology for cancer care Oracle CloudWorld, Las Vegas, 2022
Service
Served on the FASEB Generative AI Task Force (2024) and the FASEB DataWorks! Advisory Committee (2022–24). External scientific advisor to Project EAGER, an NIH-funded undergraduate genomics training program, and a member of Harvey Mudd College's Innovation Accelerator Laboratory for Emerging Health Technology.
Documents
- Academic CV Full publication, talk and teaching record · PDF
- Résumé Two pages · PDF